Endocrine Abstracts

Introduction/aim: There is growing evidence to suggest that retinal neurodegeneration is an early event in the pathogenesis of diabetic retinopathy (DR). Somatostatin (SST) has a neuroprotective action and we previously found a downregulation of SST associated with the hallmarks of retinal neurodegeneration (glial activation and apoptosis) in human retinas. The aim of the study was to test the hypothesis that SST is useful in preventing retinal neurodegeneration.<p class="...

Context: The effects of cabergoline on cardiac valves have been extensively studied in Parkinson’s disease and hyperprolactinemia but not in acromegaly, a condition at risk of cardiac valve abnormalities.Objective: We examined the prevalence of heart valve disease and regurgitation in a series of patients with acromegaly treated with cabergoline, by comparison with matched patients who had never received this drug.Design and s...

Providing good information, exchanging expertise and stimulating clinical discussions are usually main goals when structuring academic services. Nowadays, especially in large countries with social/economic differences between regions, such as Brazil, telemedicine and telehealth are resources with main strategic importance in a country’s Public Health System. Since its creation, RUTE network (Rede Universitária de Telemedicina, supported by brazilian Ministry of Scien...

Aim: To assess the effectiveness, safety and tolerability of Exenatide twice daily treatment of type 2 diabetes and obesity.Material and methods: Data analysis of obese type 2 diabetic patients initiated on Exenatide therapy in our Endocrine clinics who complete 1 year of treatment.Results: We included 42 patients, 30 women (71.4%) and 12 men (28.6%), mean (±S.D.) age 57±10 and 9±7 years diabetes evolu...

Background: Hormonal signalling plays a key role in the progression of non-alcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). However, the role of somatostatin (SST), cortistatin (CORT), neuronostatin (NST) and ghrelin systems in NAFLD-HCC progression has not been elucidated.Objectives: To characterize the role of SST/CORT/NST and ghrelin systems in chronic liver disease and evaluate its clinical potential.Met...